An overnight Russian drone-and-missile attack on 27–28 September struck Kyiv and multiple regions of Ukraine, leaving four people dead in the capital and more than 70 injured nationwide, according to the Interior Ministry.
The fatalities in Kyiv include a 12-year-old girl and two people at the Institute of Cardiology—a nurse and a patient. Emergency services reported operations at eight locations in Ukrainian capital. Two rescuers were injured during clearance work when structures collapsed.
Interior Minister Ihor Klymenko said more than 1,500 firefighters, police and emergency personnel were deployed across 11 regions to deal with fires, evacuations and structural stabilisation. Officials recorded damage to over 100 civilian sites.
President Volodymyr Zelenskyy said the assault lasted for more than 12 hours and involved nearly 500 attack drones and over 40 missiles, including Kinzhal hypersonic weapons. He identified Kyiv and Kyiv Oblast, Zaporizhzhia, Khmelnytskyi, Sumy and Odesa as the main axes of the attack. In his statement, the president linked the timing to the close of the UN General Assembly week and called for tighter international pressure on Moscow, including measures targeting revenues from energy sales and the “shadow fleet”. He appealed for coordinated action by the United States, the European Union, the G7 and the G20.
In Kyiv, the Institute of Cardiology sustained blast and fire damage. Authorities confirmed the deaths of a nurse and a patient at the facility. Municipal services said hospital operations continued on a limited basis while safety inspections were carried out and critical departments secured. Elsewhere in the city, search, evacuation and welfare checks continued in affected residential blocks. Utility teams isolated damaged lines and established cordons around unstable stairwells.
Outside the capital, regional administrations reported rising casualty figures through the day. In Zaporizhzhia, officials said the number of people wounded in morning strikes had increased to 38. Six were hospitalised, including three children; others received outpatient treatment. Preliminary surveys listed damage to 41 apartment buildings, 22 private houses and several non-residential structures. Three multi-storey blocks were disconnected from utilities pending engineering assessments.
Odesa region authorities reported further strikes by attack drones overnight. A production shop and finished-goods warehouse at a wine plant were destroyed, and a shift of 50 workers was evacuated from the site. The regional administration said there were no casualties in this incident. A private house nearby sustained roof and glazing damage.
Nationally, emergency services emphasised the risk to responders during post-strike operations, noting the injuries to two rescuers in Kyiv, and urged residents to avoid cordoned areas while inspections proceeded. Teams prioritised checks at medical facilities, multi-storey dwellings and utility nodes, and warned of potential delayed collapses where blast waves had compromised stairwells. Investigators began documenting damage at each strike site for potential criminal proceedings and compensation claims.
Officials said casualty figures remained subject to revision as debris removal continued and residents sought medical attention. By late morning on 28 September, the Interior Ministry’s tally indicated more than 70 people injured across the country. The ministry reiterated that work was ongoing at multiple locations in Kyiv and across other affected regions.
Zelenskyy said Ukraine would continue to take measures aimed at reducing Russia’s capacity to finance further attacks and pressed partners to support steps that would “force diplomacy”. He repeated calls for restrictions on Russian imports and for action against maritime logistics enabling energy exports. The president’s statement followed the pattern of previous appeals for coordinated sanctions and enforcement measures.
The overnight assault reflected recent large-scale attack profiles, with successive waves of drones and missiles directed at major urban centres and regional hubs. While local reports indicated that air-defence activity was sustained for extended periods, debris and direct impacts resulted in fatalities and damage in populated areas. Photographs from several sites showed shattered façades, smoke plumes and interior fire damage.
As recovery works continued, authorities advised residents to follow air-raid guidance, heed local instructions, and avoid approaching damaged buildings until structural engineers had completed assessments. Utility services undertook temporary disconnections where necessary and prepared for phased restoration once sites were cleared.
Key figures (as of midday, 28 September):
• Kyiv fatalities: four, including a 12-year-old girl; a nurse and a patient at the Institute of Cardiology among the dead.
• Injured nationwide: more than 70.
• Zaporizhzhia injuries: 38; six hospitalised, including three children.
• Civilian sites damaged: over 100 nationwide; responders deployed: more than 1,500 across 11 regions.
• Odesa region: wine plant shop and warehouse destroyed; 50 workers evacuated; no casualties reported.
• Scale of attack: nearly 500 attack drones and over 40 missiles, including Kinzhal.
